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黑斯佩里丁对老鼠慢性不可预测的轻度压力相关抑郁症的作用通过肠-大脑轴路径

Hui-Qing Liang^1,2, Shao-Dong Chen³, Yu-Jie Wang³

¹School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China.

Chinese journal of integrative medicine

|August 13, 2024

概括

在Citri Reticulatae Pericarpium中发现的hesperidin通过改善行为和调节肠-大脑轴来有效治疗老鼠的抑郁症. 这种天然化合物影响神经递质,肠道微生物群和结肠健康,提供了一个有前途的治疗途径.

科学领域:

药理学和神经科学药理学和神经科学
肠-大脑轴研究研究
自然产品治疗药物自然产品治疗药物

背景情况:

抑郁症是一种复杂的疾病,对全球健康产生重大影响.
肠-大脑轴,涉及肠道微生物群和中枢神经系统之间的通信,越来越被认为是抑郁症的关键因素.
传统医学中的一种Citri Reticulatae Pericarpium含有hesperidin,一种具有潜在治疗功能的黄类化合物.

研究的目的:

为了研究hesperidin的抗抑郁作用,这是Citri Reticulatae Pericarpium的一个关键组成部分.
阐明hesperidin对抑郁症作用的潜在机制,特别关注肠-大脑轴.
为了评估hesperidin对行为,神经递质水平,肠道微生物群组成和结肠组织病理学的影响,在老鼠抑郁模型中.

主要方法:

通过使用慢性不可预测的轻度压力 (CUMS) 诱导了一种老鼠抑郁模型.
行为评估包括糖偏好测试 (SPT),强迫游泳测试 (FST) 和开放场测试 (OFT).
使用ELISA测量了血清素 (5-HT) 和来自大脑的神经营养因子 (BDNF) 的水平. 通过16S rRNA基因测序分析了肠道微生物组的组成,并通过组织病理学检查了结肠组织.

主要成果:

赫斯佩里丁治疗显著改善了暴露于CUMS的老鼠的抑郁行为,改善了体重,糖糖偏好,并减少了静止时间.
赫斯佩里丁可以提高抑郁症小鼠的大脑中血清素 (5-HT) 和来自大脑的神经营养因子 (BDNF) 的水平.
素治疗积极调节了肠道微生物群,增加了香农指数,降低了辛普森指数,同时也改善了结肠组织完整性.

结论:

赫斯佩里丁在老鼠抑郁症模型中表现出显著的抗抑郁作用.
赫斯佩里丁的治疗机制涉及肠-大脑轴的调节,包括对神经递质水平,肠道微生物群和结肠健康的影响.
赫斯佩里丁是一种潜在的自然治疗抑郁症的药物,需要进一步研究.

关键词:

行为分析行为分析.慢性不可预测的轻度压力诱导的抑郁症我们的肠道微生物群.这就是hesperidin.

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