与认知障碍相关的严重更年期症状:一项探索性研究
Andrés Calle1, Juan E Blümel2, Peter Chedraui3
1From the Centro Integral de Salud Obstétrica y Femenina. Ginecología, Universidad Indoamérica, Academia Ecuatoriana de Medicina, Quito, Ecuador.
Menopause (New York, N.Y.)
|August 13, 2024
概括
严重的绝经症状与绝经后妇女的认知能力下降有关. 诸如较低的BMI,运动和激素治疗等因素可能会保护认知健康.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 神经科学是一个神经科学.
- 老年学是一门学科.
背景情况:
- 更年期显著影响女性的健康,荷尔蒙变化可能会影响认知功能.
- 认知衰退是老龄化人口日益关注的问题,需要对其贡献因素进行研究.
- 了解更年期症状与认知健康之间的关系对于开发有针对性的干预措施至关重要.
研究的目的:
- 调查绝经后妇女更年期症状的严重程度与认知障碍之间的关联.
- 确定可能影响这一人口群体认知功能的因素.
主要方法:
- 这是一项涉及9个拉丁美洲国家的1287名绝经后妇女的横截面观察研究.
- 使用更年期评分表 (MRS) 评估更年期症状;用蒙特利尔认知评估 (MoCA) 评估认知功能.
- 轻度认知障碍 (MCI) 定义为MoCA分数<21;用于分析关联的逻辑回归.
主要成果:
- 15.3%的女性患有MCI,呈现出明显更强烈的绝经症状 (MRS得分为15.24±12.58对10.53±8.84,P<0.001).
- 严重的绝经症状 (MRS ≥14) 与MCI显著相关 (OR,1.74;95% CI,1.25-2.42).
- 较低的BMI,性活动,体育炼,更年期荷尔蒙疗法使用和高等教育与MCI的几率较低有关.
结论:
- 严重的绝经症状是绝经后妇女认知障碍的重要危险因素.
- 绝经后妇女的认知健康受到荷尔蒙,生活方式和社会人口统计因素的复杂相互作用的影响.
- 进一步的研究是有必要的,以探索因果途径和治疗策略.
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