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基因预测和观察到的BMI之间的差异预测事件2型糖尿病
Tae-Min Rhee1, Jaewon Choi2, Hyunsuk Lee3,4,5
1Department of Internal Medicine, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Republic of Korea.
Diabetes care
|August 13, 2024
概括
体重指数 (BMI) 高于基因预测的人面临患2型糖尿病 (T2D) 的风险增加. 这种差异可能表明一个人与体重的遗传设定点的偏差.
科学领域:
- 遗传学和人类健康
- 代谢性疾病研究研究
- 流行病学 流行病学
背景情况:
- 肥胖是2型糖尿病 (T2D) 的主要危险因素.
- 代谢并发症不仅仅是通过体重指数 (BMI) 的升高来解释的.
- 与遗传倾向相关的BMI的个体差异可能会影响代谢健康.
研究的目的:
- 调查基因预测的BMI和观察到的BMI (BMI-diff) 之间的差异是否可以预测发生的2型糖尿病 (T2D).
- 探索BMI-diff与T2D风险之间的关联,考虑观察到的BMI.
- 在一个独立的队列中验证发现.
主要方法:
- 利用了英国生物库 (n=332,154) 和韩国基因组和流行病学研究 (KoGES,n=7,430) 队列.
- 使用PRS-CS计算的BMI多基因风险得分.
- 使用基于BMI-diff五分位数的多变量Cox比例危险模型评估了10年T2D风险.
主要成果:
- 在英国生物银行测试组中,基因预测的BMI解释了BMI变异的7.1%.
- 较高的BMI差异五分位数与T2D风险增加有显著的关联 (HR为第1个与第5个五分位数的1.61,P <0.001).
- 这些发现在KoGES队列中复制,并与胰岛素敏感性受损有关.
结论:
- 超过遗传预测的高BMI与患2型糖尿病的风险更高有关.
- BMI-diff为改进T2D风险评估提供了一个潜在的指标.
- 对BMI的遗传值可能有助于个性化T2D风险分层.
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