目前对口腔膜状细胞癌的治疗方法以及向分子治疗的转变
Mitra Elmi1,2, Joshua H Dass1,3, Crispin R Dass1,2
1Curtin Medical School, Curtin University, Perth, WA, Australia.
The Journal of pharmacy and pharmacology
|August 13, 2024
概括
放射治疗是口腔状细胞癌 (OPSCC) 的主要治疗方法,这是头癌的一个子集. 分子疗法正在出现,但主要是在临床前阶段.
科学领域:
- 在瘤学瘤学.
- 头部和部癌症研究研究
- 分子医学是分子医学.
背景情况:
- 口腔状细胞癌 (OPSCC) 是头部和部状细胞癌 (HNSCC) 的一个重要子集.
- 对OPSCC的治疗策略范围从激进的治疗意图到息性疾病控制.
- 了解OPSCC的分子机制对于推进治疗模式至关重要.
研究的目的:
- 审查口腔状细胞癌 (OPSCC) 的当前治疗选择.
- 专注于在头癌的更广泛背景下推动OPSCC的分子机制.
- 提供OPSCC管理的最新进展和未来方向的概述.
主要方法:
- 对OPSCC目前常规治疗方式的审查.
- 检查最近的进展和新兴的治疗策略.
- 对OPSCC发展和进展的分子基础的分析.
主要成果:
- 放射治疗是全球OPSCC的主要治疗方式,包括在澳大利亚,美国,英国和新西兰.
- 外科手术通常用于表面的OPSCC或部剖析,通常随后是放射治疗.
- 目前的分子疗法主要处于临床前开发阶段.
结论:
- 虽然放射治疗仍然是OPSCC治疗的基石,但分子疗法显示出希望.
- 临床试验目前正在评估向药物,如 cetuximab,nivolumab,pembrolizumab,Lenvatinib 和 bevacizumab.
- 对分子机制的进一步研究对于开发OPSCC有效的向治疗是必不可少的.
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