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Updated: Jun 17, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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通过 Stapled Peptide PROTAC 来针对蛋白质激酶A 的降解

Matthew K Whittaker1, George N Bendzunas1, Mahsa Shirani2

  • 1Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, Georgia 30602, United States.

ACS chemical biology
|August 13, 2024
PubMed
概括

研究人员开发了一种新型的堆抑制剂-PROTAC (StIP-TAC) 来降解蛋白激酶A (PKA). 这种StIP-TAC通过E3酶招募有效降解PKA,扩大了PROTAC用于挑战蛋白质标的应用.

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