混合有机-无机铜和复合物用于抗微生物潜在应用
Suhailah S Al-Jameel1,2, Ibtisam M Ababutain2,3, Azzah I Alghamdi2,3
1Department of Chemistry, College of Science, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441, Dammam, Saudi Arabia, Ssaljameel@iau.edu.sa, suhailahsaljameel@gmail.com.
概括
新的铜和曲素复合物显示出显著的抗微生物活性. 与单独的黄相比,黄-黄复合物 (Co-CUR) 对测试中的细菌和真菌表现出更高的疗效.
科学领域:
- 材料科学 材料科学 材料科学
- 药用化学 医学化学
- 微生物学 微生物学
背景情况:
- 黄素 (CUR),源自长,具有抗炎,抗菌,抗氧化和抗癌的特性.
- 黄素的治疗潜力受到生物利用性差,疏水性和快速新陈代谢的限制.
- 提高黄素的可溶性和生物利用性对于最大限度地提高其生物效应至关重要.
研究的目的:
- 合成和描述铜 (Cu) 和 (Co) 的新型杂交有机-无机复合物与.
- 评估这些合成的金属黄素复合物的抗菌潜力,以对抗致病微生物.
主要方法:
- 金属库尔库复合物 (Cu-CUR和Co-CUR) 是通过将库尔库与铜酸单水合物反应而合成的.
- 使用X射线衍射 (XRD) 和FTIR光谱进行了结构和相位识别.
- 使用标准化方法对四种细菌菌株和两种Candida物种进行了抗菌活性评估.
主要成果:
- 合成的Cu-CUR和Co-CUR复合体被发现是新的,同结构的和高度结晶的.
- FTIR分析证实了复合物的形成.
- -素复合物 (Co-CUR) 与铜-素 (Cu-CUR) 和纯素相比,对测试的微生物表现出更高的抗菌活性.
结论:
- 室温合成产生了具有显著抗微生物特性的高度结晶的铜和曲素复合物.
- 联合CUR证明了增强的抗菌潜力,优于纯黄素.
- 需要进一步的研究来阐明这些复杂物与细菌和真菌的相互作用机制.
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