邻近效应启动的超分子纳米复合物与连续透作为协同化学免疫治疗的不可逆转的亡诱导剂
Mengjie Ye1, Junfeng Hu1, Linlin Han1
1Key Laboratory of Luminescence Analysis and Molecular Sensing, Ministry of Education, School of Materials and Energy & Chongqing Engineering Research Center, for Micro-Nano Biomedical Materials and Devices, Southwest University, Chongqing, 400715, P. R. China.
一个新的纳米粒子为结直肠癌提供双重化疗药物,通过多米诺状细胞死亡机制克服耐药性并提高治疗效率. 这种方法在与免疫检查点阻塞疗法相结合时显示出希望.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 在瘤学瘤学.
背景情况:
- 结肠直肠癌 (CRC) 治疗面临着多药耐药性 (MDR) 和药物透率差的挑战.
- 目前的组合化疗方案需要改进,以获得更好的治疗结果.
研究的目的:
- 开发一种pH/redox双激活的超分子纳米粒子系统,用于增强CRC中的药物输送.
- 通过纳米粒子传递的oxaliplatin和dasatinib的协同效应的研究.
- 评估纳米颗粒与免疫检查点阻塞 (ICB) 的联合治疗.
主要方法:
- 主机-客人分子识别被用来创建DAS@CD-OxPt (IV) 纳米粒子.
- 纳米颗粒被设计用于pH触发的现场组装到瘤细胞内的纳米纤维中.
- 该研究评估了药物释放,DNA损伤,多米诺状细胞死亡和瘤抑制 in vivo.
主要成果:
- DAS@CD-OxPt (IV) 纳米颗粒证明了长时间的循环和瘤内保留.
- 在瘤细胞内发生了以质子驱动的纳米纤维组装,促进了持续的药物释放.
- 双重药物输送协同诱导DNA损伤和多米诺状的癌细胞死亡.
- 与ICB的联合治疗在CT26模型中显著抑制了瘤生长和转移.
结论:
- pH/redox双激活的超分子纳米颗粒为克服CRC耐药性提供了一个有希望的策略.
- 开发的纳米粒子系统能够有效地提供双重药物,并促进增强的抗瘤免疫力.
- 将DAS@CD-OxPt (IV) 纳米颗粒与ICB疗法结合在一起,为结直肠癌提供了一种强大的治疗方法.
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