相关实验视频

Updated: Jun 17, 2025

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

基于CQD的有针对性的多功能纳米平台的合理构建,用于协同化学-光热瘤治疗

Chenghao Liu¹, Qing Chang², Xingyan Fan³

¹Institute of Nanochemistry and Nanobiology, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China; Key Laboratory of Smart Drug Delivery, Ministry of Education, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 201203, China.

Journal of colloid and interface science

|August 13, 2024

概括

这项研究开发了一个新的纳米平台,使用碳量子点和氨酸绿色用于向化学光热癌症治疗. 该系统在临床前研究中证明了有效的药物输送,增强瘤向和显著的瘤抑制.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
在瘤学瘤学.

背景情况:

光热疗法 (PTT) 与化疗相结合,可以提供协同作用的癌症治疗.
在PTT中存在安全,稳定和高效的光热剂的需求.
碳量子点 (CQD) 是一个有前途的光热剂.

研究的目的:

开发一种向叶酸 (FA) 的光热多功能纳米平台,用于协同化学光热疗法.
在脂质体内封装CQD和多克索鲁比 (DOX),以进行向药物输送.
为了增强光热效应,并实现刺激响应的药物释放.

主要方法:

合成CQD作为光热剂.
构建FA向性脂质体,封装CQD和DOX,并嵌入印ocyanine绿色 (ICG).
评估光热转换效率,药物释放动力学,生物相容性和抗瘤疗效 in vitro 和 in vivo.

主要成果:

该纳米平台实现了高光热转换效率47.14%.
通过近红外激光 (NIR) 触发的经过控制的药物释放.
展现出出色的生物相容性,增强瘤向性,以及有效的癌细胞杀死和瘤抑制.

结论:

开发的NIR光触发,向纳米平台是协同化学-光热联合治疗的有希望的策略.
这种方法提高了治疗癌症的疗效.
纳米平台为设计先进的癌症疗法提供了一个可行的途径.

关键词:

碳量子点是一个量子点.脂质体是一种脂质体.光动力学治疗和化疗.光热疗法,协同效应疗法

更多相关视频

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance

Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance

Published on: December 13, 2015

相关概念视频

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...