睡眠开始期间心率的变化在患者的失眠与或没有并发性睡眠呼吸暂停
Yan Ma1, Janet M Mullington2, Peter M Wayne1
1Osher Center for Integrative Health, Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.
Sleep medicine
|August 13, 2024
概括
失眠的个体在睡觉前表现出高度的生理兴奋,这可以通过心率变化 (HRV) 的改变来证明. 这种自主性失调,可能会被阻塞性睡眠呼吸暂停 (OSA) 恶化,可能作为失眠和治疗有效性的生物标志物.
科学领域:
- 生理学 生理学 生理学
- 睡眠医学 睡眠医学
- 心脏病学 心脏病学
背景情况:
- 睡眠前的压力和过度兴奋是失眠障碍的关键因素.
- 在失眠中睡眠开始期间的生理变化尚未完全理解.
- 失眠和阻塞性睡眠呼吸暂停 (OSA) 经常同时发生,这表明自主调节发生了改变.
研究的目的:
- 描述睡眠开始期间心率变化 (HRV).
- 用HRV作为在失眠中潜在的睡眠前高兴度的测量.
- 探索失眠患者 (有和没有OSA) 和对照者之间的自主差异.
主要方法:
- 在患有失眠症 (不同程度的OSA) 和正常睡眠对照的参与者中描述了睡眠前HRV概况.
- 提取睡眠开始期间的心率数据用于HRV分析.
- 组间对 HRV 测量进行了比较,并对年龄,性别,BMI 和 OSA 严重程度等共变量进行了调整.
主要成果:
- 与对照组相比,失眠患者在睡眠开始时显著增加心率和降低HRV (SDNN,pNN20,pN50,较低功率).
- 失眠独立地与更高的心率,更低的PNN20和更低的高频功率有关.
- 虽然中度/严重的OSA可能会进一步影响失眠中的HRV,但这些差异在统计学上并不显著.
结论:
- 失眠与睡眠期间阴道活动减少有关,这表明心率较高和HRV较低.
- 阻塞性睡眠呼吸暂停可能会加剧这些自主性改变.
- 睡眠开始时心率动态变化可能是失眠的生理生物标志物,也是评估干预效果的工具.
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