血清脑源性神经营养因子水平在患有磁盘诱导的腰部神经根性病变的患者中:与疼痛严重程度和功能障碍的关系
Dina Mansour Kamel1, Marwa Hassan1, Noha A Elsawy1
1Physical Medicine, Rheumatology and Rehabilitation, Faculty of Medicine, University of Alexandria, Egypt.
概括
血清大脑衍生神经营养因子 (BDNF) 在磁盘诱导的腰椎神经激光病 (LSR) 中升高,并与急性神经病痛有关. 然而,BDNF水平与慢性疼痛或LSR患者的功能障碍无关.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生化学
- 整形外科 整形外科 整形外科
背景情况:
- 椎间盘诱导的腰部神经根性病变 (LSR) 是导致残疾的主要原因.
- 神经营养素,特别是来自大脑的神经营养因子 (BDNF),与疼痛机制有关.
- 以前的研究没有评估LSR患者的血清BDNF水平.
研究的目的:
- 在患有椎间盘诱导的LSR的患者中检查血清BDNF水平.
- 为了确定血清BDNF和疼痛严重程度之间的关系.
- 评估血清BDNF与LSR中的功能障碍之间的关联.
主要方法:
- 一项涉及40名LSR患者和40名健康对照者的病例控制研究.
- 神经学,电生理学和疼痛评估 (NRS,DN4).
- 使用修改的奥斯威斯特低腰痛残疾指数 (ODI) 和缅因-西雅图背部问卷 (MSBQ) 测量功能残疾.
- 血清BDNF水平使用酶相关免疫吸收试验 (ELISA) 量化.
主要成果:
- 与健康对照人群相比,LSR患者的血清BDNF水平显著更高 (P<0.001).
- 在患有神经病痛与非神经病痛的患者中观察到血清BDNF的升高 (P=0.03).
- 在血清BDNF和急性疼痛严重程度之间发现了正相关性 (NRS得分,P=0.026).
- 血清BDNF和慢性疼痛严重程度或功能障碍措施 (ODI,MSBQ) 之间没有发现显著的相关性.
结论:
- 血清BDNF增加可能与神经病痛和急性疼痛严重程度有关,在盘诱导的LSR.
- 血清BDNF水平似乎与这组患者的慢性疼痛严重程度或功能障碍无关.
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