在IgE介导卵子过敏患者中没有黄热病疫苗反应
Ruth-Helena Ramírez-Giraldo1, Paola-Andrea Giraldo-Avila1, Ana-Maria Calle1,2
1Group of Clinical and Experimental Allergology, "Alma Mater de Antioquia" Hospital, University of Antioquia, Medellín, Colombia.
International archives of allergy and immunology
|August 13, 2024
概括
患有蛋过敏的患者可以安全地接种黄热病疫苗 (YFV),而不会增加过敏反应的风险. 对YFV的过敏测试往往会导致不必要的延迟,强调疫苗接种不应该推迟.
科学领域:
- 免疫学 免疫学 免疫学
- 过敏和免疫学 过敏和免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 卵子过敏在儿童早期很常见,与疫苗接种计划相吻合.
- 对疫苗过敏反应的担忧,如黄热病疫苗 (YFV),可能导致蛋过敏个体的免疫接种延迟.
- 延迟接种疫苗会增加可预防感染的风险.
研究的目的:
- 在被诊断患有蛋过敏的患者中,确定YFV给药后过敏反应的频率.
- 评估疫苗接种前过敏测试对YFV管理和结果的影响.
主要方法:
- 追溯性,多中心队列研究分析了2014-2023年患者记录.
- 包括患有蛋过敏的患者,收集有关蛋相关反应和YFV管理的数据.
- 评估过敏测试,包括皮肤刺伤测试 (SPT) 和皮内测试 (IDT),用于蛋和YFV.
主要成果:
- 在171名患者中,23.9%的患者有卵子过敏史;5人有阳性SPT,21人有阳性YFV IDT.
- 所有患者都耐受了YFV的使用,没有过敏反应,无论测试结果或蛋过敏的严重程度如何.
- 46.1%的患者经历了YFV延迟,14%的延迟超过12个月,通常是由于测试.
结论:
- 对蛋过敏的个体对YFV发生过敏反应的风险很低.
- 疫苗接种前对YFV的过敏测试可能会导致显著的延迟,而不会提高诊断准确度.
- 应及时给蛋过敏患者,即使是那些有严重蛋反应的患者,给予YFV,以预防疾病.
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