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Updated: Jun 17, 2025

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巨细胞介导的髓回收促进了脑癌的恶性发展

Daan J Kloosterman1, Johanna Erbani1, Menno Boon1

  • 1Division of Tumour Biology and Immunology, Oncode Institute, The Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands.

Cell
|August 13, 2024
PubMed
概括

质母细胞瘤依靠它们的微环境来获取能量. 研究人员发现,含脂质的巨细胞通过转移髓脂来为癌细胞提供燃料,从而揭示了质母细胞瘤治疗的新代谢点.

关键词:
癌症免疫力胆固醇质母细胞瘤脂质新陈代谢巨细胞骨髓蛋白的回收瘤微环境

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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