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布莱蒂拉 (Bletilla striata) 的结构特征和伤口愈合作用是新鲜的结核多糖

Zining He¹, Yanfei He², Xiang Meng¹

¹College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.

International journal of biological macromolecules

|August 13, 2024

概括

来自Bletilla striata新鲜 (BSPS) 的一种新型多糖化物被表征并发现可以促进C2C12细胞活性. 在临床前研究中,BSPS显示出作为天然伤口愈合剂的巨大潜力.

科学领域:

自然产品化学自然产品化学
生物化学生物化学
药理学药理学是指药理学的学科.

背景情况:

布莱蒂拉 (Bletilla) 条纹球茎传统上用于医学.
多糖是众所周知的各种生物活动.
来自新鲜B.striata的多糖的结构和功能在很大程度上仍然没有被描述.

研究的目的:

从新鲜的B. striata tuber (BSPS) 中分离和鉴定一种同质的多糖.
为了研究BSPS对C2C12髓母细胞细胞的体外影响.
评估BSPS的体内伤口愈合潜力.

主要方法:

聚糖分离和净化. 多糖分离和净化.
使用HP-GPC,色度测量,FT-IR,甲基化,GC-MS,NMR,SEM和AFM进行了广泛的结构表征.
在体外测试细胞活力,分化,迁移和侵入.
在小鼠的体内伤口愈合模型.

主要成果:

获得了一种分子量为722.90kDa的均质多糖化物 (BSPS).
BSPS由葡萄糖和曼 (1:2.5比) 组成,具有线性链结构.
BSPS显著促进了C2C12细胞的活力,分化,迁移和入侵.
在小鼠中,BSPS加速了表皮再生和伤口愈合.

结论:

BSPS的结构不同于干燥的B.striata茎中发现的多糖.
BSPS具有强大的促再生和伤口愈合特性.
BSPS代表了一个有前途的新型天然化合物用于伤口愈合应用.

关键词:

布莱蒂拉 (Bletilla striata) 是一种多糖化合物.结构性表征结构性表征伤口愈合活动的伤口愈合活动

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