肠道微生物群,维生素A缺乏和自闭症谱系障碍:一个相互关联的三人组 - - 一个系统性审查
Fatima Ezzahra Kacimi1, Latifa Didou2, Soumia Ed Day2
1Biotechnology and Sustainable Development of Natural Resources Unit, Multidisciplinary Faculty, Sultan Moulay Slimane University, Beni Mellal, Morocco.
Nutritional neuroscience
|August 13, 2024
概括
患有自闭症的儿童表现出改变的肠道微生物群 (GM),可能与维生素A缺乏 (VAD) 相关. 早期的VAD可能会影响自闭症的发病,而维生素A补充剂可能是一个有前途的治疗方法.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 营养科学 营养科学
背景情况:
- 患有自闭症的儿童经常出现胃肠道问题.
- 在自闭症和非自闭症儿童之间观察到肠道微生物群 (GM) 组成的显著差异.
- 营养因素,特别是维生素缺乏,越来越多地被调查为自闭症的贡献者.
研究的目的:
- 系统地审查自闭症,肠道微生物群变化和维生素A缺乏 (VAD) 之间的关系.
- 探索转基因变化的潜力作为自闭症生物标志物.
- 研究维生素A补充剂在自闭症中的治疗潜力.
主要方法:
- 2010年至2022年间从PubMed和Embase发布的研究的系统审查.
- 选择了19项遵循PRISMA指南的研究.
- 对自闭症,转基因变异和VAD之间的关联进行分析.
主要成果:
- 在患有自闭症的人群中,转基因成分的显著变化表明了作为生物标志物的潜力.
- 在自闭症患者和VAD患者之间,没有发现转基因成分的显著差异.
- 在降低的视网膜酸水平和自闭症症状严重程度之间观察到相关性.
结论:
- 肠道微生物群的变化与自闭症密切相关,可以作为诊断标记.
- 维生素A缺乏,特别是在生命的早期,可能会导致自闭症的发展.
- 维生素A补充值得进一步研究,因为它是对自闭症症状的潜在干预措施.
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