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结构,功能和有效连接在双相情感障碍的诊断价值

Teodora M Gencheva¹, Bozhidar V Valkov¹, Sevdalina S Kandilarova^2,3

¹Faculty of Medicine, Medical University of Plovdiv, Plovdiv, Bulgaria.

Acta psychiatrica Scandinavica

|August 13, 2024

概括

这篇评论强调了双相情感障碍 (BD) 中的大脑连接的差异. 在BD患者中改变了结构,功能和有效的连接模式,显示出作为诊断的神经成像生物标志物的潜力.

科学领域:

神经成像是一种神经成像.
精神病学是一个精神病学.
大脑的连接性大脑的连接性

背景情况:

双极性障碍 (BD) 的诊断可能具有挑战性.
像fMRI这样的神经成像技术提供了潜在的生物标志物.
了解大脑连接的差异至关重要.

研究的目的:

系统地审查功能磁共振成像 (fMRI) 对双相情感障碍 (BD) 的研究.
与对照人群相比,对BD患者的结构,功能和有效连接性差异的特征.
评估这些连接模式作为诊断神经成像生物标志物的潜力.

主要方法:

在PUBMED和SCOPUS进行了系统的文献搜索.
自2015年以来发表的专注于双相情感障碍连接性的研究也包括在内.
遵循系统审查和元分析 (PRISMA) 准则的首选报告项目.

主要成果:

包括60项研究:20项是结构性,33项是功能性,7项是有效连接性.
在结构连接中发现了额头,环状皮质和情绪/奖励网络中的异常.
最常见的功能连接发现:小脑 (vermis) 到大脑. 在显著性,默认模式和执行控制网络中标注的变化,以实现有效的连接.

结论:

尽管异质,但在双相情感障碍中出现了不同的连接模式.
改变的大脑连接性显示为BD的诊断生物标志物具有前途.
未来使用更大样本和机器学习的研究可能会加速诊断生物标志物的采用.

关键词:

双相情感障碍是双相情感障碍的一种疾病.有效的连接,有效的连接.功能磁力共振成像 (fMRI) 是一种功能连接性的功能连接性结构连接性的结构连接性

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