使用Heliox进行连续的阿尔布特罗尔输送的儿科基板模型
Jie Li1, Raghad R Abulkhair2, Fai A Albuainain3
1Department of Cardiopulmonary Sciences, Division of Respiratory Care, Rush University, Chicago, Illinois. jie_li@rush.edu.
振动网状雾化器 (VMN) 带有高流量鼻腔管 (HFNC) 或紧紧的口罩在儿科模型中提供了最多的阿尔布特罗尔与氧. 这种设置比MiniHEART雾化器或带有松散口罩的VMN更有效.
科学领域:
- 儿科呼吸系统护理服务
- 药理动力学和药物输送
- 氧 (heliox) 疗法是一种氧疗法.
背景情况:
- 在儿科中,最佳的连续阿尔布特罗尔与赫里奥克斯的输送尚未得到充分证实.
- 了解高效的雾化器设置对于有效的阿尔布特罗尔管理至关重要.
研究的目的:
- 用不同的雾化器设置来比较连续阿尔布特罗尔与赫里奥克斯输送的效率.
- 为了评估在各种heliox给药配置下的儿科模型中的albuterol气溶沉积.
主要方法:
- 一个模拟呼吸的儿科玩偶通过三种设置接收连续的阿尔布特罗尔 (20毫克/小时) 和赫里奥克斯 (80/20) 通过三种设置:MiniHEART雾化器,振动网雾化器 (VMN) 与高流量鼻 (HFNC),和VMN与非再呼吸面罩.
- 测试了紧身和松身的口罩,以及不同的氧比率 (70/30和80/20).
- 在收集气溶沉积后,使用紫外线光谱仪量化药物输送.
主要成果:
- 使用HFNC的VMN和使用紧身面具的VMN实现了最高的吸入阿尔布特罗尔剂量 (约8.5-8.8%).
- MiniHEART雾化器导致气溶沉积显著降低 (1.5%).
- 紧身面罩和80/20氧混合物分别提供了较高的吸入剂量,相比松面罩和70/30氧混合物.
结论:
- 在闭口呼吸期间与HFNC一起使用VMN是儿童模型中使用heliox连续输送albuterol的最有效的设置.
- 这种方法在吸入药物剂量方面超过了MiniHEART雾化器和VMN带宽式口罩.
- 这些发现为优化儿科患者的赫力奥克斯-阿尔布特罗尔治疗提供了指导.
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