在患有全身性硬化症的患者中评估dysautonomia,胃肠道过境和临床表型之间的关联
Maria Paula Alvarez-Hernandez1, Brittany Adler2, Jamie Perin3
1Hospital Universitario de La Princesa, Madrid, Spain.
Arthritis care & research
|August 13, 2024
概括
系统性硬化症患者有显著的胃肠道问题经常经历全球自主功能障碍 (GAD). GAD与有限的皮肤SSc和更快的胃肠道过渡有关,这表明一个独特的临床子组.
科学领域:
- 胃肠病学 胃肠病学
- 类风湿病学 类风湿病学
- 神经学 神经学
背景情况:
- 系统性硬化症 (SSc) 是一种复杂的自身免疫性疾病,影响多个器官系统.
- 胃肠道 (GI) 功能障碍是SSc的常见和衰弱的表现.
- 自主神经系统 (ANS) 功能障碍或dysautonomia在SSc中越来越多地得到认可.
研究的目的:
- 为了识别SSc患者具有高负荷的自主症状.
- 为了确定这些患者是否表现出明显的临床表型,胃肠道过境或肠外特征.
- 调查SSc.中的dysautonomia和GI参与之间的关联.
主要方法:
- 研究了91名患有肠道疾病的SSc患者的前性队列.
- 用复合自主症状评分 (COMPASS) -31问卷进行评估.
- 消化道过渡通过全肠扫描测量,并系统地收集临床数据.
主要成果:
- 33%的SSc患者表现出全局自主功能障碍 (GAD),与67%的有限自主功能障碍 (LAD) 相比.
- 在有限的皮肤SSc中,GAD更为普遍,并与Sicca症状相关.
- 患有GAD的患者表现出更快的胃和结肠过境和更高的COMPASS-31分数,其中包括上部肠道部位.
结论:
- 全球性失自性影响高达三分之一的SSc患者的胃肠道参与.
- 在SSc中确定GAD的临床特征可以帮助向调节ANS的向疗法.
- 这突出了一个特定的SSc人群,他们可能会受益于以自治为重点的干预措施.
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