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胎儿治疗先天性肺形:一个前性的基于人口的国家队列研究

Mathilde Weber¹, Isabelle Monier², Makan Rahshenas²

¹Service de Gynécologie-Obstétrique, Hôpital Antoine Béclère, AP-HP, Université Paris Saclay, Clamart, France.

Prenatal diagnosis

|August 13, 2024

概括

对先天性肺形 (CPM) 的胎儿治疗是罕见的. 与没有治疗的胎儿相比,接受干预的胎儿显示出更糟糕的结果,包括更低的生存率.

科学领域:

医学研究医学研究
胎儿医学胎儿医学
出生异常是先天的异常.

背景情况:

先天性肺形 (CPM) 是一组影响胎儿肺部发育的疾病.
对CPM的胎儿干预措施的利用和结果的评估对临床实践至关重要.

研究的目的:

为了确定被诊断为CPM的胎儿的胎儿治疗频率.
调查接受胎儿治疗的CPM胎儿的短期周产期结果,与没有接受胎儿治疗的胎儿相比.

主要方法:

在法国 (2015-2018) 进行的一项基于全国人口的队列研究,包括435名患有CPM的单独胎儿.
从医疗记录中收集了CPM体积比 (CVR),压缩迹象,胎儿治疗类型和围产期结果的数据.
使用统一变量统计测试来比较胎儿与胎儿治疗和没有胎儿治疗之间的结果.

主要成果:

只有6.0%的患有CPM的胎儿接受胎儿治疗,包括胸腔膜切换,产前类固醇或组合.
接受治疗的胎儿表现出更高的CVR和更严重的压缩迹象.
与未接受治疗组相比,接受胎儿治疗组的活产率较低 (84.6%),住院死亡率更高 (13.6%),而未接受治疗组的活产率 (98.5%,1.0%死亡率).

结论:

胎儿治疗在少数患有CPM的胎儿中使用.
与未接受治疗的胎儿相比,接受胎儿治疗的胎儿在周围产生的结果明显更差,包括生存率降低,与未接受治疗的胎儿相比.

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