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在儿童中抗脂综合征

Mojca Zajc Avramovic¹, Tadej Avcin¹

¹Department of Allergology, Rheumatology and Clinical Immunology, University Children's Hospital, University Medical Center Ljubljana, Slovenia; Department of Pediatrics, Faculty of Medicine, University of Ljubljana, Slovenia.

Best practice & research. Clinical rheumatology

|August 13, 2024

概括

儿科抗脂综合征 (APS) 呈现严重的频繁的血栓事件和独特的非血栓特征. 本综述涵盖了儿童APS的临床表现和新兴疗法,包括新生儿病例.

科学领域:

儿科风湿病学儿科风湿病学
血液学血液学血液学
免疫学免疫学免疫学

背景情况:

儿童的抗脂综合征 (APS) 罕见但严重,与成人相比,血栓形成和灾难性APS的风险更高.
非血栓性表现在儿科APS中很常见,并且可能在血栓性事件之前发生.
最近的APS分类标准需要对儿科患者进行评估.

研究的目的:

为儿童患者提供与抗脂抗体 (aPL) 相关的临床表现的全面概述.
分析已发表的队列和来自国际儿科APS注册表的数据.
为了说明由于母性aPL转移而导致婴儿的APS,重点关注围产期血栓形成和神经发育结果.

主要方法:

关于儿科抗脂综合征的已发表队列的审查.
来自国际儿科APS注册表的数据分析.
对新生儿APS的病例研究进行了审查,该病例来自胎盘外母性aPL转移.

主要成果:

小儿APS表现出更严重的表现,频繁的血栓复发,与成人APS相比,灾难性APS的发病率更高.
非血栓形成的症状在儿童中更为普遍,并且可能发生在血栓形成事件之前.
新生儿APS是由于母亲的aPL引起的,很少引起急性围产期血栓,但与长期的神经发育问题有关.

结论:

由于其严重程度和独特的临床过程,儿科APS需要专门的管理.
新型疗法,包括B细胞和补充抑制剂,显示出希望,特别是在灾难性的APS.
了解跨胎盘aPL转移对于管理新生儿风险和长期神经发育随访至关重要.

关键词:

抗心脂蛋白抗体是一种抗体.抗脂抗体是一种抗脂抗体.灾难性的抗脂蛋白综合征孩子孩子孩子孩子科雷亚科雷亚科雷亚婴儿抗脂综合征的发生狼抗凝剂狼抗凝剂系统性红血性狼 (Systemic lupus erythematosusus) 是一种全身性狼.血小板减少症 (Thrombocytopenia) 是一个严重的疾病.血栓形成的原因是血栓形成.抗β2 糖蛋白 I 抗体的抗体.

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