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Updated: Jun 17, 2025

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma DIPG
08:46

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma DIPG

Published on: March 7, 2017

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通过稳定PTEN,SVIP减少IGFBP-2的表达,并通过稳定PTEN抑制质母细胞瘤的进展

Zixuan Wang1,2, Xiaolong Qiao3, Yinan Chen1

  • 1Department of Neurosurgery, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China.

Cell death discovery
|August 13, 2024
PubMed
概括

小VCP/P97-交互蛋白 (SVIP) 通过抑制STUB1和稳定PTEN抑制质母细胞瘤 (GBM) 的生长. 这种机制减少了IGFBP-2和PI3K/AKT/mTOR通路的激活,为GBM提供了一个新的治疗标.

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