流行病学和血液生物标志物分析的整合将血红铁摄入量与2型糖尿病风险增加联系起来
Fenglei Wang1, Andrea J Glenn1,2,3, Anne-Julie Tessier1
1Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Nature metabolism
|August 13, 2024
概括
饮食中的血红铁摄入量,但不是非血红铁,显著增加了2型糖尿病 (T2D) 的风险. 这种联系是由等离子体生物标志物如L-瓦林和尿酸介导的,影响脂质和炎症.
科学领域:
- 营养科学 营养科学
- 代谢学 代谢学 代谢学
- 流行病学 流行病学
背景情况:
- 饮食中的血红铁摄入与2型糖尿病 (T2D) 风险增加有关.
- 这种关联背后的特定的血生物标志物和代谢途径仍然不清楚.
研究的目的:
- 调查饮食中铁摄入量与T2D风险之间的关联.
- 确定可能调解血铁和T2D之间的关系的血代谢生物标志物.
主要方法:
- 分析了长达36年的美国三大队列中204,615名参与者的数据.
- 对37544名参与者的血代谢生物标志物和9024名参与者的代谢概况的评估.
- 用多变量调整的考克斯比例危险模型来检查铁摄入量和T2D风险.
主要成果:
- 血红铁摄入量,但非血红铁摄入量与较高的T2D风险显著相关 (HR 1.26; 95% CI 1.20-1.33,比较最高和最低的五分位数).
- 血红铁摄入与不良的血形状相关,包括胰岛素血,脂质和炎症.
- 代谢物,如L-瓦林和尿酸被确定为铁-T2D关系的潜在调解者.
结论:
- 饮食中血红铁的摄入量是T2D的重要危险因素,独立于非血红铁.
- 血代谢概况,包括脂质,胰岛素血症和炎症,因高血红铁摄入而发生不利变化.
- 特定的代谢物,特别是L-氨酸和尿酸,可能在介导血红铁和T2D之间的病原性联系方面发挥关键作用.
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
2.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.3K
Psychoneuroimmunology: Diabetes and Cancer
27
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
27
Diabetes Mellitus: Overview and Type I Subtype
2.5K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.5K
Pathophysiology of Diabetes
910
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
910
Diabetes: Symptoms, Diagnosis, and Complications
520
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
520
Carbohydrate Metabolism
10.9K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
10.9K


