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哺乳对早产婴儿微生物组和代谢组的影响:试点研究
Keriann Schulkers Escalante1, Shiyu S Bai-Tong1, Sarah M Allard2
1Department of Pediatrics, University of California San Diego, Rady Children's Hospital, La Jolla, CA, USA.
Pediatric research
|August 13, 2024
概括
过渡早产婴儿从输液管到口服养改变了他们的唾液微生物组和代谢组,并改变了母亲的牛奶成分. 这些变化,特别是唾液的变化,可能为未来的疾病风险生物标志物提供.
科学领域:
- 微生物组研究的研究.
- 代谢学 代谢学 代谢学
- 新生儿营养新生儿营养
背景情况:
- 母乳对于早产婴儿至关重要.
- 养过渡对婴儿微生物组和新陈代谢组的影响尚未完全理解.
研究的目的:
- 调查早产婴儿从输卵管过渡到口服/母乳养如何影响他们的口腔和肠道微生物组和代谢组.
- 在此过渡期间分析母乳成分的变化.
主要方法:
- 对早产婴儿及其母亲进行前性观察研究.
- 在四个纵向时间点分析便,唾液和牛奶样本.
- 使用先进技术进行微生物组和代谢组分析.
主要成果:
- 唾液微生物组发生了转变,口服养后的链球菌增加和葡萄球菌减少.
- 牛奶样本的代谢物受养途径和类型的影响,涉及维生素E,B12和托芬代谢.
- 没有观察到婴儿便微生物组或代谢组的显著变化.
结论:
- 养过渡显著改变早产儿的唾液微生物组和代谢组,以及母乳成分.
- 婴儿唾液代谢物质的变化显示出可能成为疾病风险的生物标志物.
- 该研究强调了养方法,牛奶和婴儿发育中的微生物组和代谢组之间的动态相互作用.
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