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在中国的老年食道癌患者中,MFI-11具有术后不良结果
Xiu Chen1, Yan Dang1, Qi Zhang1
1Department of Thoracic Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230000, China.
BMC geriatrics
|August 13, 2024
概括
患有食道癌症的老年患者身体脆弱,面临更高的术后并发症风险. 11指数修改的脆弱指数 (mFI-11) 有效地识别这些高风险个体,有助于手术护理规划.
科学领域:
- 老年医学 老年医学
- 手术瘤学手术瘤学
- 临床流行病学临床流行病学
背景情况:
- 脆弱性越来越被认为是老龄化人口不良结果的重要预测因素.
- 它是影响各种医学专业的预后的一个关键因素.
- 了解虚弱的影响对于管理老年患者,特别是那些接受手术的患者至关重要.
研究的目的:
- 调查通过11指数修改的脆弱指数 (mFI-11) 评估的脆弱性与接受食道癌手术的老年患者的术后并发症之间的关联.
- 评估mFI-11对食道癌外科治疗后不良临床结果和并发症的预测价值.
主要方法:
- 一个回顾性队列研究包括515名患者 (≥65岁),他们接受了为食道癌进行手术治疗.
- 患者被分为脆弱 (mFI-11高) 和非脆弱 (mFI-11低) 的两组,使用0.27.7的mFI-11截止值.
- 结果包括术后并发症 (感染,心律失常,,胸,电解质干扰),ICU停留,住院时间,再入院和死亡率.
主要成果:
- 虚弱组 (35.1%) 与非虚弱组 (64.9%) 相比,所有评估的术后并发症的发生率显著更高.
- mFI-11在预测并发症方面表现出强大的预后能力,ROC曲线下的面积 (AUROC) 值从0.707到0.832.
- 虚弱的患者肺部感染 (85.1%与26.6%) 和心律失常 (61.9%与9.9%) 的发病率显著更高.
结论:
- 老年食道癌患者手术前的虚弱与术后并发症的高发病率有关.
- 11指数修改的脆弱指数 (mFI-11) 作为一个客观和有效的工具来识别处于危险的老年患者.
- 利用mFI-11可以帮助优化手术风险评估和患者管理在这个脆弱的人群.
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