带状疹和主观认知衰退的长期风险
Tian-Shin Yeh1,2,3,4,5,6, Gary C Curhan7,8,9, Barbara P Yawn10
1Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, No.250, Wuxing St, Taipei, 11031, Taiwan. tianshin.yeh@gmail.com.
Alzheimer's research & therapy
|August 13, 2024
概括
疹 (shingles) 与主观认知衰退 (SCD) 的长期风险更高有关. 这种风险可能因APOE ε4载体状态和疫苗接种史而有所不同.
科学领域:
- 神经科学是一个神经科学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 疹 (HZ) 或带状疹被怀疑通过神经炎症或神经元损伤导致认知能力下降.
- 现有证据表明,HZ和认知衰退之间的纵向联系是不一致的.
- APOE ε4 载体状态的影响和 HZ 疫苗接种对认知衰退的影响仍未得到充分研究.
研究的目的:
- 为了前性地研究疹疹 (HZ) 病史与随后的主观认知衰退 (SCD) 之间的关联.
- 基于APOE ε4载体状态来探索这种关联中的潜在差异.
- 检查HZ疫苗接种与长期SCD风险之间的关系.
主要方法:
- 分析了来自三个大型前队伍的149,327名参与者:护士健康研究 (NHS),NHSII和卫生专业人员随访研究 (HPFS).
- 使用波桑回归计算多变量调整的SCD相对风险 (MVRR),基于从HZ诊断以来的时间.
- 小组分析考虑了APOE ε4载体状态和HZ疫苗接种史.
主要成果:
- 与没有HZ的人相比,有HZ病史的个人表现出明显更高的SCD风险.
- 增加SCD风险的持续时间因群体而异,在NHS (≥13年) 和NHS II (短期和长期) 中观察到长期关联.
- 由APOE ε4载体状态和HZ疫苗接种表明,与HZ相关的SCD风险存在潜在差异,尽管研究结果并不完全一致.
结论:
- 疹疹 (HZ) 与主观认知衰退 (SCD) 的长期风险增加有关,在大型,独立的队列中.
- HZ和SCD之间的关联可能受到APOE ε4载体状态的影响.
- 需要进一步的研究来澄清HZ疫苗接种对认知衰退的影响.
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