相关实验视频

Updated: Jun 17, 2025

Facile Preparation and Photoactivation of Prodrug-Dye Nanoassemblies

Facile Preparation and Photoactivation of Prodrug-Dye Nanoassemblies

Published on: February 17, 2023

高功能的pH触发超分子纳米用于向癌症化疗

Muhammad Kawish¹, Samina Parveen², Nimra Naz Siddiqui³

¹International Centre for Chemical and Biological Sciences, H.E.J Research Institute of Chemistry, University of Karachi, Karachi, Pakistan.

Pharmaceutical development and technology

|August 13, 2024

概括

这项研究开发了适应pH的纳米 (BCD-QUE-BZMSN),用于向化疗. 这些纳米显示出对肺癌和肝癌细胞的增强细胞毒性疗效,改善药物向性和生物可用性.

科学领域:

纳米技术纳米技术
材料科学材料科学材料科学
药理学药理学是指药理学的学科.

背景情况:

化疗药物输送面临诸如短半衰期,生物可用性差,缺乏向性等挑战.
开发先进的药物输送系统对于有效的癌症治疗至关重要.

研究的目的:

设计和表征pH响应的混合纳米颗粒 (BCD-QUE-BZMSN) 用于向素的输送.
为了评估这些纳米膜对肺癌和肝癌细胞系的疗效.

主要方法:

合成带有素 (QUE) 的化 (BZ-MSN) 覆盖的半孔性化纳米粒子.
用β-环极素 (BCD) 进行封装,形成BCD-QUE-BZMSN.
使用FTIR,EDX,NMR,XRD,UV和SEM进行表征.
在体外药物释放研究和细胞毒性测定对癌症细胞系.

主要成果:

BCD-QUE-BZMSN纳米颗粒的直径为~115nm,泽塔电位为~7mV.
证实了高的药物捕获效率和球形形态.
观察到受控的,依赖于pH值的药物释放,在轻度酸性的癌细胞环境中增强了疗效.
与单独使用奎尔丁相比,获得了显著的细胞毒性疗效和细胞吸收.

结论:

开发的BCD-QUE-BZMSN纳米是一种有前途的载体,用于向癌症化疗.
响应pH的药物输送系统可以克服传统化疗药物的局限性.
这种纳米制剂表明了改善癌症治疗策略的潜力.

关键词:

带有本齐米达涂层的半孔二氧化纳米颗粒.化学疗法化疗化疗纳米可以使用.适应pH值的纳米粒子目标药物输送的目标药物输送.

更多相关视频

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery

Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery

Published on: June 23, 2020

相关概念视频

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...