基于人口的Helicobacter pylori查与根除的成本效益,以实现最佳实施年龄
Akiko Kowada1,2
1Department of Occupational Health, Kitasato University Graduate School of Medical Sciences, Sagamihara, Kanagawa, Japan.
Helicobacter
|August 14, 2024
概括
在15岁实施Helicobacter pylori查为预防胃癌 (GC) 提供了最具成本效益的策略. 这种早期查方法最大限度地提高了益处,并最大限度地降低了初级GC预防的成本.
科学领域:
- 胃肠病学 胃肠病学
- 预防医学 预防医学
- 卫生经济学 卫生经济学
背景情况:
- 查和根除Helicobacter pylori (H. pylori) 可以减少胃癌 (GC) 的发生率.
- 启动H. pylori查以获得最大的成本效益的最佳年龄仍未确定.
- 这项研究确定了H. pylori查最具成本效益的年龄,以预防GC.
研究的目的:
- 确定以人口为基础的H. pylori查的最佳年龄,以预防初级胃癌.
- 评估不同年龄段的H. pylori查与没有查或内镜相比的成本效益.
主要方法:
- 从医疗保健支付者的角度开发了一个国家过渡模式.
- 分析了H. pylori检测的9个年龄段 (15-80岁).
- 结果包括成本,QALY,预期寿命,GC病例和GC相关死亡;进行了敏感性分析.
主要成果:
- 在任何年龄段 (15-80) 进行H. pylori查比不进行查或内镜检查更具成本效益.
- 15岁时的查显示了最大的成本节约和效益.
- 查1560万名15岁儿童预计将节省970万美元,预防436例GC病例,并避免176例GC死亡,而不是没有查.
结论:
- 基于人口的H. pylori查的最佳年龄是15岁.
- 查年轻人群体的H. pylori可以显著减少全球的GC发病率和死亡率.
- 需要进一步研究早期根除H. pylori的可行性和长期影响.
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