Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Bipolar Disorder01:30

Bipolar Disorder

60
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
60
Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

155
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
155
Traits, Mood, and Subjective Wellbeing01:22

Traits, Mood, and Subjective Wellbeing

68
Subjective well-being (SWB) refers to an individual's self-evaluation of their overall life satisfaction, happiness, and fulfillment. This multifaceted construct is typically assessed by analyzing the balance of positive and negative emotions alongside perceptions of life satisfaction. Personality traits such as neuroticism and extraversion are strongly associated with variations in SWB, offering critical insights into the underlying mechanisms of emotional well-being.
Neuroticism and...
68

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Functional connectivity correlates of reaction time variability in treatment-resistant major depression.

Psychological medicine·2026
Same author

Brain lithium temporospatial kinetics in bipolar disorder: a repeated-measures <sup>7</sup>Li MRI study of dosing regimens in Germany.

The lancet. Psychiatry·2026
Same author

Selective molecular and network architecture features underlie brain cortical atrophy in dementia with Lewy bodies.

Journal of biomedical science·2026
Same author

The utility of a composite endpoint for tracking disease progression in Lewy body dementia.

Alzheimer's & dementia (New York, N. Y.)·2026
Same author

Identification of prognostic biomarkers in a large cohort of patients with LGMD R2.

Journal of neurology·2026
Same author

Solar Flare Detection from Sudden Ionospheric Disturbances in VLF Signals via a CNN-HMM Framework.

Sensors (Basel, Switzerland)·2026

相关实验视频

Updated: Jun 17, 2025

Basics of Multivariate Analysis in Neuroimaging Data
06:35

Basics of Multivariate Analysis in Neuroimaging Data

Published on: July 24, 2010

16.8K

在euthymic双极性障碍中的多变量大脑认知关联

Bethany Little1,2, Carly Flowers1, Andrew Blamire1

  • 1Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

Bipolar disorders
|August 14, 2024
PubMed
概括

双相情感障碍 (BD) 患者在处理速度 (PS) 和执行功能 (EF) 中表现出认知障碍. 这些缺陷与特定时大脑区域的异常皮质厚度相关.

关键词:
关注注意力注意力注意力注意力双相情感障碍是双相情感障碍的一种疾病.大脑皮层厚度 大脑皮层厚度认知功能障碍 认知功能障碍认知功能 认知功能认知障碍 认知障碍是一种认知障碍.执行职能 执行职能是指执行职能.多变量分析多变量分析.神经心理学神经心理学处理速度 处理速度.

更多相关视频

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

6.5K
Brain Imaging Investigation of the Impairing Effect of Emotion on Cognition
16:08

Brain Imaging Investigation of the Impairing Effect of Emotion on Cognition

Published on: February 1, 2012

16.1K

相关实验视频

Last Updated: Jun 17, 2025

Basics of Multivariate Analysis in Neuroimaging Data
06:35

Basics of Multivariate Analysis in Neuroimaging Data

Published on: July 24, 2010

16.8K
Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

6.5K
Brain Imaging Investigation of the Impairing Effect of Emotion on Cognition
16:08

Brain Imaging Investigation of the Impairing Effect of Emotion on Cognition

Published on: February 1, 2012

16.1K

科学领域:

  • 神经科学是一个神经科学.
  • 精神病学是一个精神病学.
  • 认知科学 认知科学

背景情况:

  • 双极性障碍 (BD) 与广泛的认知障碍有关.
  • 处理速度 (PS),注意力和执行功能 (EF) 是 BD 中的核心缺陷.
  • 在BD中大脑认知关联尚未完全理解,通常受到小样本大小和单变量分析的限制.

研究的目的:

  • 为了研究认知障碍 (PS,注意力,EF) 和优性双相情感障碍患者的结构性大脑异常之间的关系.
  • 使用规范建模来对皮层异常进行可靠的估计.
  • 应用多变量统计方法来分析大脑认知关联.

主要方法:

  • 在euthymic BD患者 (n=56) 和健康对照者 (n=26) 中对PS,注意力和EF进行神经心理测试.
  • 用T1权重的MRI扫描来评估皮质厚度.
  • 使用公共数据集 (n=5977) 开发规范模型,以识别患者特异性皮质异常.
  • 规范性相关性分析以检查多变量大脑认知关联,控制共变量.

主要成果:

  • 与对照组相比,BD患者在PS,注意力和EF方面表现出显著的损伤.
  • 在BD患者的多个大脑区域观察到异常的皮质厚度.
  • 损伤的PS和EF最强烈地与左下,右,右极区域的皮质厚度降低有关.

结论:

  • 在euthymic BD中存在PS,注意力和EF的认知缺陷,并且与部区域的异常皮质厚度有关.
  • 规范模型和多变量方法对于研究BD中复杂的大脑认知关系是有价值的.
  • 未来的研究应该探索各种结构性大脑指标 (例如皮质厚度,体积,表面积) 之间的共变性.