布罗利祖马布加上 cetuximab 与新辅助化学疗法治疗头部和部状细胞癌
Zhuowei Yao1, Jingshuo Wang1, Yongquan Jiang1
1Department of Otolaryngology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Head & neck
|August 14, 2024
概括
新辅助剂 pembrolizumab加上化疗的 cetuximab 在头部和部状细胞癌 (HNSCC) 中显示出高的疗效和安全性,改善了器官的保存. 治疗前的免疫标志物可以预测患者对这种免疫化疗方案的反应.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 头部和部癌症研究研究
背景情况:
- 头癌细胞经常表达PD-L1和EGFR,这是免疫反应的关键调节者.
- 布罗利祖马布 (PD-1 抑制剂) 和 cetuximab (EGFR 抑制剂) 是有效的疗法,通常与 HNSCC 的化疗相结合.
研究的目的:
- 评估HNSCC患者新辅助免疫化学疗法的疗效和安全性.
- 探索治疗反应和免疫估计器之间的相关性.
主要方法:
- 对21名接受新辅助免疫化学疗法和激进手术治疗的HNSCC患者的回顾性分析.
- 主要终点:主要病理反应 (MPR). 二次分析:免疫估计和治疗疗效.
主要成果:
- 在66.7%的患者中实现了MPR,其中11人实现了病理完整反应 (pCR).
- 总体响应率 (ORR) 为90.5%,完全响应率 (CR) 为28.6%.
- 口腔瘤反应最快;贫血是最常见的不良事件 (61.9%). 没有发生4级AE或手术延迟. 喉保存率为90.9%,负边际.
结论:
- 新辅助药布罗利祖马布,塞图西马布和化疗是HNSCC的可行和安全的方案,促进器官的保存和生活质量.
- 治疗前的周围免疫标记 (淋巴细胞计数,单细胞计数,PLR) 可能有助于识别可能从这种新辅助方法中受益的患者.
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