血清25-基维生素D与中风的关联:观察调解和孟德尔随机化研究
Ming-Chieh Tsai1,2,3, Hsien-Yu Fan1,4, Hsin-Yin Hsu1,3,5
1Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei 10055, Taiwan.
The Journal of clinical endocrinology and metabolism
|August 14, 2024
概括
维生素D水平较高与中风风险较低有关. 控制血压可能有助于预防维生素D缺乏个体中风.
科学领域:
- 心血管流行病学心血管流行病学
- 营养科学 营养科学
- 遗传流行病学遗传流行病学
背景情况:
- 连接血清25-基维生素D (25(OH) D与中风风险及其生物机制的流行病学证据有限.
- 了解维生素D状态和脑血管事件之间的关系对于公共卫生至关重要.
研究的目的:
- 为了研究血清25(OH) D度与中风风险之间的关联.
- 探索这种关系中的潜在调解因素,如高血压.
- 使用孟德尔随机化方法验证发现.
主要方法:
- 一项以社区为基础的前性队列研究 (中山社区心血管队列) 与1778名参与者进行了超过12年的跟踪.
- 使用双样本门德尔随机化 (MR) 研究进行外部验证.
- 统计分析包括COX比例危险比率,中介分析和MR.
主要成果:
- 较高的血清25(OH) D度与较低的中风风险显著相关 (HR:0.64;95% CI:0.43-0.96).
- 调解分析表明,高血压在25...OH) D-中风关联中可能发挥作用,尽管在调整后的模型中并不完全显著.
- 两个样本的MR证实了基因决定的25(OH) D和中风风险 (OR:0.92;95%CI:0.85-0.99) 之间存在显著的反向关联.
结论:
- 血清25(OH) D水平升高与中风风险降低有关.
- 高血压可能起到调解作用,强调了血压管理的重要性.
- 旨在优化维生素D水平和管理高血压的干预措施可能对预防中风有益.
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