在非贫血全血献血者中,与缺铁相关的症状
J Karregat1,2,3, A Meulenbeld1,2,3, J Abubakar1
1Department of Donor Medicine Research, Sanquin Research, Amsterdam, The Netherlands.
Transfusion
|August 14, 2024
概括
患有非贫血铁缺乏症 (NAID) 的全血献血者报告说,他们感到疲劳,但这种症状与男性较低的费里水平无关. 捐赠者的费里丁检测应专注于预防贫血,而不是缓解NAID症状.
科学领域:
- 血液学 血液学 血液学
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 全血献血者容易患铁缺乏症 (ID).
- 缺铁性贫血 (IDA) 与疲劳和认知功能障碍等症状有关.
- 这些症状在非贫血铁缺乏症 (NAID) 中是否发生仍然不清楚.
研究的目的:
- 为了研究非贫血铁缺乏症 (NAID) 与全血献血者ID相关症状之间的关联.
- 为了确定是否有疲劳,认知功能障碍,皮卡和不安腿综合征 (RLS) 等症状存在于NAID的捐赠者中.
主要方法:
- 结合了来自三项研究的12,143名全血献血者的数据 (献血者洞察-III,FIND'EM,FORTE).
- 使用验证的问卷评估自我报告的ID相关症状.
- 使用后勤回归来分析费里水平 (0-15μg/L,15-30μg/L,>30μg/L) 与症状发生之间的关系,控制共变量.
主要成果:
- 分析了来自9,829名符合条件的捐赠者的数据.
- 只有疲劳在男性捐赠者中与费里水平具有统计学意义的关联.
- 在男性中,较高的费里水平与较低的疲劳概率相关 (OR 1.41,95% CI 1.11-1.79).
结论:
- 非贫血性铁缺乏症 (NAID) 仅在男性捐赠者中与自我报告的疲劳有关.
- 潜在的选择偏差可能导致对关联的低估.
- 捐赠者的费里丁水平评估应优先考虑贫血预防,而不是管理NAID症状.
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