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相关概念视频

Overview of Hematopoiesis01:20

Overview of Hematopoiesis

3.9K
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
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Hematopoiesis01:21

Hematopoiesis

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The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
5.2K
Lineage Commitment01:21

Lineage Commitment

3.0K
Commitment is the  process whereby stem cells:
3.0K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.0K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.2K
Production of Formed Elements01:34

Production of Formed Elements

1.3K
Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
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Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
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[老化和克隆性血液形成.]

A N Bogdanov1,2, S V Voloshin3,4,5, E O Kunevich3

  • 1Saint-Petersburg State University, 7-9 University embankment, St. Petersburg 199034, Russian Federation,

Advances in gerontology = Uspekhi gerontologii
|August 14, 2024
PubMed
概括
此摘要是机器生成的。

衰老会增加体质突变,导致不确定潜力的克隆性血液形成 (CHIP). 在老年人中常见的CHIP标志着血液细胞的突变,并与健康风险有关.

关键词:
通过DNA甲基化.衰老的衰老 衰老的衰老克隆性血液形成 (clonal hematopoiesis) 是一种细胞形成的过程.遗传表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表造血干细胞是造血干细胞的组成部分.身体突变是体质突变.

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Author Spotlight: Advancing Hematopoietic Research Using Stromal Cell Isolation for Single Cell Sequencing
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科学领域:

  • 遗传学和表观遗传学
  • 衰老研究研究 衰老研究
  • 血液学 血液学 血液学

背景情况:

  • 随着年龄的增长,体内突变会在各个组织中累积,特别是在造血干细胞 (HSC) 中.
  • 克隆性造血,以突变的HSCs的扩张为特征,在老年人中很普遍.
  • 不确定潜力的克隆性血液形成 (CHIP) 涉及血液细胞的体质突变,没有恶性病变.

研究的目的:

  • 探索克隆造血和CHIP在衰老和疾病发展中的作用.
  • 调查表观遗传衰老,CHIP和不良健康结果之间的关联.
  • 了解CHIP作为各种疾病的独立风险因素的影响.

主要方法:

  • 对血造干细胞中与年龄相关的体质突变的分析.
  • 不确定潜力的克隆性血液形成 (CHIP) 的定义和鉴定.
  • 表观遗传衰老标志物与CHIP流行率和健康结果的相关性.

主要成果:

  • CHIP是老年人常见的现象,与DNMT3A和TET2.2等基因的突变有关.
  • CHIP是血液恶性瘤,心血管疾病和死亡率的独立风险因素.
  • 表观遗传衰老和CHIP的结合与不良健康结果有关.

结论:

  • CHIP是一个与衰老相关的重大现象,具有广泛的健康影响.
  • 表观遗传衰老与CHIP结合,表明健康风险增加.
  • 需要进一步的研究来探索CHIP在疾病和潜在干预中的作用.