维生素D和维生素D结合蛋白水平在COVID-19重症监护室患者:一个前性的多中心研究
Vesile Örnek Diker1, Gülseren Yılmaz2, Muhammed Emin Düz3
1Mehmet Akif Ersoy T.C.S. Training and Research Hospital, Medical Biochemistry, Istanbul, Turkey.
Journal of medical biochemistry
|August 14, 2024
概括
在COVID-19的ICU患者中,维生素D结合蛋白 (DBP) 水平较低,他们的死亡率也较高. 然而,维生素D和DBP水平与这些重症监护室患者的死亡率没有相关性.
科学领域:
- 关键护理医学 关键护理医学
- 传染性疾病 传染性疾病
- 内分泌学 在内分泌学.
背景情况:
- 维生素D结合蛋白 (DBP) 对于维生素D的运输和免疫功能至关重要.
- 在重症监护室 (ICU) 检查COVID-19患者和没有COVID-19患者的DBP和炎症标志物至关重要.
研究的目的:
- 为了比较COVID-19阳性和阴性ICU患者之间的维生素D,DBP和炎症标志物.
- 评估这些标志物,死亡率和ICU停留时间之间的关系.
主要方法:
- 一项多中心研究涉及37名COVID-19阳性和51名COVID-19阴性ICU患者.
- 测量了25 (OH) 维生素D,DBP,CRP,PCT,D-二聚合物,TNT,IL-6和费里的含量.
- 分析了生存率,死亡率和ICU持续时间.
主要成果:
- COVID-19患者的费里丁和CRP水平较高,但DBP,TnT和D-二聚体水平较低.
- 在COVID-19阳性ICU患者中,死亡率明显较高 (OR: 3.012).
- 在维生素D或DBP水平与死亡率之间没有发现显著的相关性.
结论:
- 所有ICU患者都表现出维生素D水平较低,无论COVID-19状态如何.
- 与现有文献相反,COVID-19患者的D-二次数和TnT比对照组低.
- 在COVID-19ICU患者中降低DBP需要进一步调查,可能包括DBP基因多态性研究.
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