代谢综合征和狼性炎活动之间的关联
Violeta Rabrenović1, Milica Petrović1, Milorad Rabrenović2
1Military Medical Academy, Clinic of Nephrology, Belgrade.
Journal of medical biochemistry
|August 14, 2024
概括
狼性炎 (LN) 患者的代谢综合征 (MetS) 与年龄较大,功能较差和吸烟有关. 这突显了LN患有MetS的患者心血管风险的增加.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 类风湿病学 类风湿病学
- 心脏病学 心脏病学
背景情况:
- 代谢综合征 (MetS) 加剧了系统性红斑狼 (SLE) 的心血管并发症.
- 在患有狼性炎 (LN) 的患者中,经常在初始诊断时观察到MetS.
- 了解LN中的MetS对于管理动脉样硬化和心血管风险至关重要.
研究的目的:
- 确定LN患者中MetS的患病率和特征.
- 为了调查 MetS 组件与 LN 疾病活性之间的关联.
- 确定导致LN心血管并发症的因素.
主要方法:
- 一项临床研究涉及67名LN患者 (80.59%为女性,平均年龄为42.86).
- 患者根据MetS的存在 (35.82%) 或缺乏 (64.18%) 进行分类.
- 监测了临床和生化参数,包括疾病活性 (活性LN 50.74%,缓解49.25%).
主要成果:
- 患有MetS的患者年龄较大,BMI较高,静脉血压升高,更有可能吸烟.
- MetS与增加的甘油三,肌素和减少的白蛋白和GFR有关.
- 动脉高血压是最常见的MetS成分 (76.6%),与GFR和肌素相关.
结论:
- 在LN患者中,MetS与晚年,功能受损和吸烟有关.
- 动脉高血压和脂质失调是流行的MetS成分,与疾病活动标志物相关.
- 这些发现表明,LN患有MetS的患者心血管风险较高.
更多相关视频
10:21Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
406
10:31An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment
Published on: April 20, 2018
10.7K
相关概念视频
The JAK-STAT Signaling Pathway
8.7K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
8.7K
Autoimmune Disorders
398
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
398
Renal Corpuscle
1.8K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
1.8K
Overview of Protein Metabolism
900
Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
900
