血清生物标志物可动态预测瘤治疗患者心血管事件风险. 一个多中心的观测研究
Nicoletta Provinciali1,2, Marco Piccininno3, Giacomo Siri4
1Division of Medical Oncology, Ente Ospedaliero Ospedali Galliera, 16128 Genoa, Italy.
Reviews in cardiovascular medicine
|August 14, 2024
概括
接受治疗的癌症患者面临更高的心血管风险. 随着时间的推移,基线纤维素和热波宁的升高,以及D-二次数和血压的升高,预测了这些事件,突出显示了监测的必要性.
科学领域:
- 瘤学中的心血管疾病风险
- 在癌症患者中的生物标志物分析.
- 氧化应激和心血管事件
背景情况:
- 血清生物标志物被研究用于与癌症相关的心血管 (CV) 风险预测.
- 目前的分析往往忽略了随着时间的推移生物标志物的变化.
- 炎症和氧化应激 (OS) 标志物需要进一步调查它们与心血管事件的关联.
研究的目的:
- 研究癌症治疗期间血清生物标志物的纵向变化的预测作用.
- 评估用于预测CV事件的常用和OS相关的生物标志物.
主要方法:
- 观测性研究招募75岁以上或更年轻的患有高心血管风险的患者.
- 在基线和治疗期间评估生物标志物.
- 使用了考克斯模型,亚种群治疗效应模式图 (STEPP) 和重复措施分析.
主要成果:
- 纳入182名患者;168名可评估患者,28例CV事件发生在中位数9.2个月的随访期间.
- 基线纤维素 (HR=3.95) 和热素 (HR=2.48) 的升高是独立的心血管事件风险因素.
- 随着时间的推移,在CV事件患者中观察到增加的D-二分体,血压和减少的射出分数.
结论:
- 随着时间的推移,更高的基线纤维素和热素,以及随着时间的推移增加的D-二次体和血压,与癌症患者心血管风险增加相关.
- 这项研究表明,需要进一步评估氧化应激在纤维素升中的作用.
- 对于正在接受治疗的癌症患者,建议对D-二聚体和血压进行纵向监测.
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