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案例报告:在复发性和耐火性外骨髓性多发性骨髓瘤中,双重向的BCMA和CS1CAR-T细胞免疫疗法
Xiangjun Shi1, Yue Wu2, Xingchen Yao2
1Department of Rheumatology and Immunology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Frontiers in immunology
|August 14, 2024
概括
针对BCMA和CS1的CAR-T细胞疗法在治疗多发性骨髓瘤的外骨髓性复发时表现出有限的疗效. 瘤中MYBL2表达的增加可能会阻碍治疗的成功,这表明需要新的治疗策略.
科学领域:
- 血液学 血液学 血液学
- 免疫治疗是一种免疫疗法.
- 在瘤学瘤学.
背景情况:
- 化学抗原受体T细胞 (CAR-T) 免疫疗法改善了多发性骨髓瘤治疗.
- 目前的CAR-T战略针对的是BCMA,CS1,CD38,FcRH5和GPRC5D.
- 挑战包括抗原逃逸,有限的CAR-T细胞持久性和瘤微环境的复杂性,导致复发.
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