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聚醇通过肠道微生物群改善非酒精性脂肪性肝病:综合性审查

Kimia Mohammadhasani¹, Mohammad Vahedi Fard¹, Ali Mottaghi Moghaddam Shahri²

¹Department of Nutrition, Food Sciences and Clinical Biochemistry, School of Medicine, Social Determinants of Health Research Center Gonabad University of Medical Sciences Gonabad Iran.

Food science & nutrition

|August 14, 2024

概括

聚可以通过调节肠道微生物群 (GM) 和改善肠道屏障功能来积极影响非酒精性脂肪性肝病 (NAFLD). 酸和黄素等特定化合物在缓解NAFLD症状和进展方面表现有前途.

科学领域:

营养科学营养科学
胃肠病学胃肠病学
微生物学微生物学

背景情况:

非酒精性脂肪肝 (NAFLD) 是一个日益严重的全球健康问题.
肠道微生物群 (GM) 失调和肠道屏障功能受损与NAFLD病变有关.
多,植物衍生化合物,具有抗炎和抗氧化特性.

研究的目的:

审查多对转基因成分和肠道屏障功能的影响.
评估这些修改对NAFLD的后续影响.
确定具有NAFLD潜在治疗益处的特定多.

主要方法:

进行了对英语文学的非系统性审查.
在主要的科学数据库 (Web of Science,PubMed,EMBASE,Scopus) 中进行了搜索.
审查的重点是研究聚醇,转基因,肠道屏障和NAFLD的研究.

主要成果:

聚醇,包括基酸,黄素和白醇,可以调节转基因成分和功能.
通过多醇调节转基因,通过减少肝脂肪,炎症和肝酶来改善NAFLD.
聚醇增强肠道屏障的完整性,改善血清脂质概况,通过转基因代谢物 (SCFA,LPS,BA,胆) 影响NAFLD.

结论:

某些多 (酸,白醇,素,黄素) 在调节转基因并改善NAFLD肠道屏障完整性方面表现出潜在的潜力.
需要进一步的研究来证实其他多的安全性和有效性,如纳灵,硫,和catechins在NAFLD管理.

关键词:

这是NAFLD.我们的肠道微生物组.非酒精性脂肪性肝病是非酒精性脂肪性肝病.聚醇是一种多的化合物.

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