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Updated: Jun 17, 2025

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
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发现和描述一个化学探针的循环素依赖的激酶-Like2的化学探针

Frances M Bashore1, Sophia M Min1, Xiangrong Chen2

  • 1Structural Genomics Consortium (SGC), UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.

ACS medicinal chemistry letters
|August 14, 2024
PubMed
概括

研究人员开发了基于乙胺基醇的抑制剂,以向循环素依赖类激酶2 (CDKL2). 化合物9是一种强效和选择性的CDKL2抑制剂,在细胞试验和神经元模型中得到验证,但对细胞活力没有影响.

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