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Updated: Jun 17, 2025

Author Spotlight: Evaluating Biophysical Assays for Characterizing PROTACS Ternary Complexes
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Author Spotlight: Evaluating Biophysical Assays for Characterizing PROTACS Ternary Complexes

Published on: January 12, 2024

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对于无法治疗的目标,PROTAC复杂动态的相互作用:对三元复杂行为和链接器设计的洞察

Harish Kumar1, Masilamani Elizabeth Sobhia1

  • 1Department of Pharmacoinformatics, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar (Mohali), 160062 Punjab, India.

ACS medicinal chemistry letters
|August 14, 2024
PubMed
概括

这项研究研究了蛋白质降解剂 (PROTACs) 与E3结合酶的结合动态. 了解这些相互作用是设计更有效的向蛋白质降解疗法的关键.

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