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Updated: Jun 17, 2025

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism
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Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism

Published on: July 28, 2017

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2'-O-基-N3-甲基尤里丁功能化乘客链通过调节热稳定性来改善RNAi活动

Avijit Sahoo1, Shalini Gupta2, Gourav Das1

  • 1Department of Chemistry, Indian Institute of Technology Kharagpur, West Bengal 721302, India.

ACS medicinal chemistry letters
|August 14, 2024
PubMed
概括

修改的小干扰RNA (siRNA) 与基于m3U的破坏性修改可以通过改善向导链纳入RISC复合体来增强基因沉默活性. 这些修改为改进RNA干扰疗法提供了潜力.

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