评估COPD患者的三重治疗的坚持和坚持:一项德国声称数据研究
Claus F Vogelmeier1, Kai-Michael Beeh2, Michael Schultze3
1Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Centre Giessen and Marburg, Philipps-University Marburg, German Center for Lung Research (DZL), Marburg, Germany.
International journal of chronic obstructive pulmonary disease
|August 14, 2024
概括
单吸入器三重疗法 (SITT) 与多吸入器三重疗法 (MITT) 相比,在德国COPD患者中显著改善了坚持和持续性. 在SITT选项中,流动松酸/尤克利迪尼/维兰特罗尔 (FF/UMEC/VI) 显示了最高的坚持性和持久性.
科学领域:
- 肺部病理学 肺部病理学
- 药物经济学 药物经济学
- 现实世界的证据.
背景情况:
- 对于有复发性恶化症状的COPD患者,建议进行三重治疗.
- 多次吸入器三重疗法 (MITT) 与患者不理想的坚持和治疗持续性有关.
- 单吸入器三重疗法 (SITT) 为改善治疗结果提供了一个潜在的替代方案.
研究的目的:
- 在德国COPD患者队列中比较SITT和MITT之间的坚持和持久性.
- 为了评估不同的三重疗法吸入器策略的现实世界的有效性.
主要方法:
- 对WIG2基准数据库的回顾性分析 (2017年11月至2019年6月).
- 包括开始使用特定药物组合的三重治疗 (MITT或SITT) 的COPD患者.
- 通过覆盖日数比例 (PDC) 测量坚持;持久性定义为治疗中止间隔 (>30天).
- 用于基线特征平衡的治疗权重反向概率 (IPTW).
主要成果:
- 在6,12和18个月内,SITT用户的PDC平均值明显高于MITT用户.
- 在SITT选项中,流动松酸/尤克利迪尼/维兰特罗尔 (FF/UMEC/VI) 显示了最高的PDC.
- 在前6个月内,FF/UMEC/VI和formoterol/beclomethasone/glycopyrronium bromide (FOR/BDP/GLY) 用户的坚持率高于MITT用户.
- 在18个月后,FF/UMEC/VI用户 (16.5%) 的持久性明显高于MITT用户 (2.3%).
结论:
- 与MITT相比,SITT显著提高了德国COPD患者的坚持和持续性.
- 在SITT集团中,FF/UMEC/VI组合表现出优越的坚持和持久性.
- 现实数据支持SITT作为改善COPD管理的首选策略.
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