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在PBMC中的FLI1有助于在与战斗有关的创伤后应激障碍中增加炎症

Pengfei Li^1,2, Liu Liu¹, Shufeng Liu³

¹Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, United States.

Frontiers in psychiatry

|August 14, 2024

概括

友性白血病病毒整合1 (FLI1) 在患有创伤后应激障碍 (PTSD) 的退伍军人中升高. 抑制免疫细胞中的FLI1减少了炎症和大脑微质激活,这表明PTSD的新治疗点.

科学领域:

神经科学是一个神经科学.
免疫学免疫学免疫学
遗传学是一个遗传学.

背景情况:

创伤后应激障碍 (PTSD) 涉及免疫失调和炎症标志物升高.
朋友白血病病毒整合1 (FLI1),ETS转录因子,与其他疾病的炎症有关.
目前尚未探索FLI1在PTSD相关炎症中的作用.

研究的目的:

研究FLI1在与PTSD相关的免疫失调中的作用.
探索FLI1对PTSD患者细胞中炎症性细胞因子产生的影响.
评估针对PTSD针对FLI1的治疗潜力.

主要方法:

从患有和没有PTSD的退伍军人那里收集了外周血液单核细胞 (PBMC).
在不同的免疫细胞子集 (CD4 +,CD8 + T 细胞) 中测量了FLI1表达.
使用LPS刺激PBMCs,使用Gapmers击倒FLI1,并与HMC3微细胞共同培养.

主要成果:

在PTSD PBMC中观察到显著增加的FLI1表达,特别是在CD4+ T细胞中.
在PTSD PBMC中,LPS刺激增加了FLI1和炎症性细胞因子 (IL-6,IFNγ).
在共同培养模型中,FLI1敲击降低了细胞因子水平,并减轻了微质激活.

结论:

在PBMC中FLI1表达升高与PTSD有关.
准FLI1可能会重新平衡免疫活动,并减少PTSD中神经炎症.
抑制FLI1为PTSD提供了一个潜在的新疗法策略.

关键词:

FLI1 FLI1 的意思是什么?这是PBMC的PBMC.创伤后应激障碍 (PTSD) 是一种反感的寡核化物.这是一种炎症炎症炎症炎症.

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