同时的缺氧和巴罗反射负荷对对同情作用潜能子群的控制的相互作用
Natasha G Boyes1, Stephen A Klassen2,3, Sarah E Baker2
1Department of Nutrition & Exercise Physiology, University of Missouri, Columbia, Missouri, United States.
Journal of neurophysiology
|August 14, 2024
概括
动脉巴罗反射主要控制交感神经活动,即使在竞争信号,如缺氧. 这项研究表明,巴罗反射负载降低了同情作用潜在收益,尽管化学反射激活,但这种效应仍然存在.
科学领域:
- 心血管生理学心血管生理学
- 自主神经系统的调节规则
- 神经科学是一个神经科学.
背景情况:
- 消极肌肉交感神经活动 (MSNA) 是通过动脉巴罗反射来调节的.
- 巴罗反射对MSNA中中型的同情行动潜力 (AP) 亚群产生重大影响.
- 以前的研究表明,巴罗反射负荷可以取消对缺氧的同情反应.
研究的目的:
- 为了研究不同大小的AP集群的巴罗反射控制.
- 描述在巴罗反射和联合巴罗反射/化学反射 (低氧) 激活下同情的AP亚群的神经招募策略.
主要方法:
- 健康的年轻男子使用单独的烯 (PE) 和缺氧 (80%) 进行了动脉气质受体负载.
- 使用基于波形的方法提取了同情的AP.
- 量化了单个AP集群的巴罗反射增益,测量了AP巴罗反射值增益.
主要成果:
- 烯降低了MSNA和AP的发射,但这种效果在并发性缺氧期间丢失了.
- 巴罗反射负荷降低了中型AP集群的巴罗反射值斜率和放电概率.
- 这些减少在同时缺氧期间持续存在,这表明巴罗受体占主导地位.
结论:
- 动脉巴罗反射在调节中等大小的APs以控制血压方面发挥着至关重要的作用.
- 这种巴罗反射调制能够承受来自外围化学反射激活的竞争信号.
- 这些发现表明,动脉巴罗反射在中等大小的交感神经元上起着主要的调节作用,即使有竞争性化学反射信号.
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