在Streptomyces细菌中,基因组挖掘用于核糖体合成和翻译后修饰的 (RiPPs)
Abdullah Al Mamun1, Khorshed Alam2, Farjana Akter Koly3
1Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka, Bangladesh.
Journal of Asian natural products research
|August 14, 2024
概括
410个Streptomyces序列的基因组挖掘揭示了4098个核糖体合成的翻译后修饰 (RiPPs). 土壤细菌是这些新型自然产品的丰富来源,为未来的健康补救措施提供了潜力.
科学领域:
- 微生物学 微生物学
- 生物化学 生物化学
- 自然产品 化学 化学
背景情况:
- 核糖体合成的翻译后改性 (RiPPs) 是一种新型的生物活性天然产品.
- 细菌Streptomyces是各种自然产品的丰富生产者,包括许多生物活性化合物.
- 在Streptomyces中描述生物活性天然产物基因集群的全谱仍然是一个挑战.
研究的目的:
- 在Streptomyces基因组中识别和描述RiPPs.
- 探索土壤息的Streptomyces作为新型RiPPs的来源的潜力.
- 为未来的药物发现工作提供一个全面的RiPP数据集.
主要方法:
- 410个Streptomyces基因组序列的基因组挖掘.
- 使用生物信息学工具BAGEL和anti-SMASH进行RiPP识别.
- 数据分析整合了来自国家生物技术信息中心 (NCBI) 的信息.
主要成果:
- 在分析的Streptomyces基因组中,共确定了4098个RiPP.
- 确定的RiPP包括两种分类类型 (兰氏,细菌素等). 和新型未分类变体.
- 土壤被证实是RiPP发现的高生产性环境.
结论:
- 在Streptomyces的基因组中,存在着庞大且在很大程度上尚未开发的RiPPs.
- 已确定的RiPPs,特别是来自土壤环境的RiPPs,代表了新型治疗剂的有希望的候选者.
- 这项研究扩大了RiPPs已知的多样性,并突出了它们在应对各种健康挑战方面的潜力.
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