在患有青少年异常性关节炎的儿童中验证EQ-5D-Y-5L父母代理版本
Arto Ohinmaa1, Jiabi Wen1, Gillian R Currie2,3,4
1School of Public Health, University of Alberta, Edmonton, Canada.
概括
EQ-5D-Y-5L父代理版本是测量青少年异常性关节炎 (JIA) 儿童生活质量的有效工具. 这项研究证实了其对JIA患者群体的构造有效性和信息性.
科学领域:
- 儿科 儿科 儿科
- 类风湿病学 类风湿病学
- 健康 结果 研究 研究 结果
背景情况:
- 青少年异常性关节炎 (JIA) 是最常见的儿童关节炎,导致关节疼痛和潜在的身体损伤,影响移动性.
- 虽然EQ-5D-Y-3L版本已被验证用于JIA,但EQ-5D-Y-5L父代理版本的心理特征仍然未经检查.
研究的目的:
- 在被诊断为JIA的儿童中评估EQ-5D-Y-5L父代理版本的心理测量特性.
- 评估EQ-5D-Y-5L的有效性和信息性,用于测量儿科JIA患者的与健康有关的生活质量.
主要方法:
- 利用了来自"理解儿童关节炎网络" (Understanding Childhood Arthritis Network) 加拿大-荷兰合作研究队列的数据.
- 评估心理测量特性,包括天花板/地板效应,收/分歧有效性 (斯皮尔曼等级相关性),已知组有效性 (ANOVA) 和信息性 (香农平衡指数).
- 从新发病的JIA患者和接受生物治疗的患者收集了临床数据,CHAQ和EQ-5D-Y-5L母代理版本.
主要成果:
- 分析了407名患者的467次患者访问;EQ-5D-Y-5L显示没有天花板或地板效应.
- 显示出良好的收有效性 (例如,疼痛维度与CHAQ疼痛指数,r=0.74) 和分歧有效性 (例如,疼痛与CHAQ饮食,r=0.19).
- 显示出强大的已知群体有效性,区分活跃和非活跃疾病 (p<0.001,ES=1.20),信息性指数范围为0.52至0.88.
结论:
- 在这个JIA队列中,EQ-5D-Y-5L父代理版本显示了可接受的构造有效性和信息性.
- 研究结果表明,EQ-5D-Y-5L父代理版本是评估JIA儿童生活质量的合适工具.
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