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细菌膜囊泡的喷雾干燥用于疫苗输送

Gregor Fuhrmann1,2, Mina Mehanny3

  • 1Department of Biology, Pharmaceutical Biology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. gregor.fuhrmann@fau.de.

Methods in molecular biology (Clifton, N.J.)
|August 14, 2024
PubMed
概括

喷雾干燥稳定了细菌细胞外囊泡,以改善疫苗配方. 这种方法提高了疫苗的稳定性,而不损害它们的保护性免疫反应,使它们成为有希望的疫苗候选人.

关键词:
抗原是一种抗原.细菌膜囊泡是一种细菌膜囊泡.细胞外囊泡中的细胞外囊泡.喷雾干燥 喷雾干燥疫苗 疫苗 疫苗 疫苗

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Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...