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多瘤病毒ALTOs,但不是MTs,通过激活NF-κB通路来降低病毒早期基因表达的调节

Nicholas J H Salisbury1, Supriya Amonkar1, Joselyn Landazuri Vinueza1,2

  • 1Human Biology Division, Fred Hutchinson Cancer Center Seattle, WA 98109.

Proceedings of the National Academy of Sciences of the United States of America
|August 14, 2024
PubMed
概括

默克尔细胞多瘤病毒替代LT开放读取框架 (ALTOs) 通过激活NF-κB信号和降低病毒转录的调节,起到瘤抑制作用. 对默克尔细胞癌的发展而言,ALTO沉默至关重要.

关键词:
爱斯坦·巴尔病毒病毒.梅克尔细胞癌瘤是什么?在 NF-κBB 中.另一个LT开放阅读框架 (ALTO)这种病毒是多聚马病毒.

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