追踪进化:对药物相互作用的综合图书法分析 临床研究
Lanping Li1, Yushi Zhou1, Lika Ye1
1Phase I Clinical Trial Center, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Journal of clinical pharmacology
|August 14, 2024
概括
本文献分析揭示了临床环境中药物相互作用 (DDI) 的研究日益增加,突出了安全性,新陈代谢和个性化医疗等关键主题. 它要求协调方法和先进的分析来改善药物治疗.
科学领域:
- 药理学和临床研究.
- 圣经计量学和科学计量学
- 药物的安全性和有效性.
背景情况:
- 药物相互作用 (DDI) 在临床实践中带来了重大挑战.
- 了解DDI的研究环境对于推进药物治疗至关重要.
- 以前的文献分析没有全面地绘制出临床研究中DDI的演变.
研究的目的:
- 在临床研究中对DDI进行第一个全面的文献分析.
- 为了确定进化趋势,核心主题,以及该领域的研究热点.
- 为未来的研究方向和方法的全球协调提供见解.
主要方法:
- 在科学网络核心集合中对临床环境中的DDI进行图书统计搜索.
- 使用分析工具,包括DIKW,VOSviewer和Citespace进行模式分析.
- 包括从3421个识别出版物的初始池中的2622个相关文章.
主要成果:
- 观察到DDI出版物的显著增加,在2020年达到顶峰.
- 确定了五个主要的主题集群:安全性/不良反应,新陈代谢/有效性,疾病/治疗,方法/实践以及特殊人群/组合药物.
- 关键的见解包括药物代谢日益重要,重点关注心血管/抗病毒药物,以及个性化医学的进步.
结论:
- 这项研究强调了药物代谢日益重要的意义,以及DDI研究中个性化医学的趋势.
- 需要将战略重点放在弱势群体和创新的研究方法上.
- 呼吁全球协调研究方法,将个性化医学和先进的计算分析纳入DDI临床研究.
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