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循环中的CD39+FoxP3+Treg细胞的暂时增加预测了早期类风湿性关节炎中对甲状腺素的临床反应

Alejandro Villalba¹, Laura Nuño¹, Marta Benito-Miguel²

¹Department of Rheumatology, Hospital Universitario La Paz-IdiPaz, Madrid, Spain.

Rheumatology (Oxford, England)

|August 14, 2024

概括

在早期类风湿性关节炎 (eRA) 中,较高的CD39+调节性T细胞 (Treg39+) 基线频率预测了对甲状腺酸盐 (MTX) 的更好的反应. 甲基增强Treg39+细胞功能,有助于控制炎症.

科学领域:

免疫学免疫学免疫学
类风湿病学类风湿病学
药理学药理学是指药理学的学科.

背景情况:

CD39+调节性T细胞 (Treg39+) 将促炎性核酸水解成抗炎剂腺素.
甲基 (MTX) 可能通过增加腺核酸挤出来增强Treg39+细胞功能.

研究的目的:

研究Treg39+细胞与MTX在早期类风湿性关节炎 (eRA) 的疗效之间的关系.
为了确定基线Treg39+细胞频率是否预测eRA患者的MTX反应.

主要方法:

来自98名eRA患者和98名健康对照者的外周血液淋巴细胞的流细胞计分析.
82名患者在12个月的MTX治疗后进行临床再评估和重复细胞计.
在体外评估MTX对共同培养中的Treg细胞功效的影响.

主要成果:

与健康对照人群相比,eRA患者基线Treg39+细胞频率升高.
较高的Treg39+基线频率与12个月的MTX后实现低疾病活性 (LDA) 有显著的相关性.
基线Treg39+细胞频率为42.0%预测了具有高灵敏度和特异性的LDA.
在体外,MTX增加了Treg39+细胞的活性,但并没有增加Treg39-细胞.

结论:

在eRA中,MTX与Treg39+细胞合作控制炎症.
基线Treg39+细胞频率是eRA中MTX响应的预测生物标志物.
在eRA中暂时升高的基线Treg39+细胞可能表明MTX启动的最佳窗口.

关键词:

CD39 CD39 是一个氨酸 (Adenosine) 是一种氨酸.在早期的类风湿性关节炎.甲基特雷克萨酸盐的使用方法贸易细胞是指贸易细胞.

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