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干细胞和B细胞的对话增强了IL-33丰富的淋巴细胞,以支持在2型免疫期间的氨基细胞的招募和功能

Emily Bessell¹, Rachel E Finlay², Louisa K James³

¹William Harvey Research Institute (WHRI), Barts & The London School of Medicine & Dentistry, Queen Mary University of London (QMUL), London, UK; Institute of Tissue Medicine and Pathology, University of Bern, Bern, Switzerland; Institute of Parasitology, Vetsuisse Faculty, University of Bern, Bern, Switzerland; Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland.

|August 14, 2024

概括

埃索诺菲尔对中腔淋巴结的招募对于2型免疫是至关重要的. 干细胞和B细胞的相互作用决定了乙氨基细胞的生存和回归,影响宿主对寄生虫的防御.

科学领域:

免疫学免疫学免疫学
细胞生物学细胞生物学

背景情况:

乙氨基是对抗多细胞生物体的关键免疫细胞.
在2型免疫期间,中腔淋巴结 (mLN) 异氨基细胞的招募情况尚不清楚.

研究的目的:

调查2型免疫期间在mLN中调控乙氨基细胞招募和功能的机制.
阐明 stromal 细胞和 B 细胞在 mLN 阴中所扮演的角色.

主要方法:

使用了缺乏特定B细胞信号分子 (IL-4Rα, LTβ) 的转基因小鼠.
检查了与淋巴结层 (FRCs,淋巴内皮细胞) 的埃奥西诺菲尔关联.
评估了对树皮细胞和B细胞相互作用的反应中的乙氨基细胞存活率,激活率和受体表达.

主要成果:

在缺乏B细胞IL-4Rα或LTβ的小鼠中,与mLN stromal niches的埃索诺菲尔相关性降低了.
干细胞和B细胞的对话驱动着乙素细胞的存活,激活和Il1rl1受体表达.
在FRC上对淋巴毒素-β受体的结合增强了乙氨基细胞的存活率,IL-33表达和mLN定位.
缺乏乙氨基酸的小鼠表现出MLN扩张的减少,警报蛋白的表达,以及虫清除的延迟.

结论:

流体细胞和B细胞交叉是mLN胆氨酸友好症和有效的2型免疫力必不可少的.
淋巴毒素信号传递在粒细胞招募到mLN中起着至关重要的作用.
乙素对宿主对虫的防御至关重要,其功能取决于mLN免疫微环境.

关键词:

B细胞是B细胞的组成部分.CCL24 CCL24 CCL24 CCL24 CCL24 CCL24 CCL24 CCL24 CCL24 CCL24 CP: 免疫学免疫学这种动物叫Heligmosomoides polygyrus.这里有IL-33和IL-33.它们的IL-4Rα.埃索诺菲尔细胞的存在纤维细胞的网状细胞.淋巴内皮细胞是淋巴内皮细胞.介质性淋巴结之间的淋巴结.树皮细胞树皮细胞

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