将卡巴马泽平切换为拉克萨米德改善了玛-氨基转酶水平
Yuichi Kubota1,2, Mario Prado1,3
1Department of Neurosurgery, Adachi Medical Center, Tokyo Women's Medical University, Tokyo, Japan.
Epilepsia open
|August 14, 2024
概括
在患者中,从碳胺 (CBZ) 转换为胺 (LCM) 显著降低了肝酶 (GGT) 的升高. 这种改变在一个月内是有效和安全的,发作发生率没有增加.
科学领域:
- 神经学 神经学
- 肝病学 肝病学是一种肝病学.
- 临床药理学 临床药理学
背景情况:
- 卡巴马泽 (CBZ) 是用于焦点的标准抗发作药物 (ASM),但由于不良反应而存在局限性,特别是胺转移酶 (GGT) 的升高表明肝脏毒性.
- 患者的高GGT水平与死亡率增加有关,可能需要改变治疗方法.
研究的目的:
- 在成年患者中,研究从卡巴马西平 (CBZ) 突然切换到拉科萨米德 (LCM) 的疗效和安全性.
- 评估这种药物切换对GGT水平和控制的影响.
主要方法:
- 一项研究包括焦点的成年患者 (18岁以上),控制发作超过2年,接受稳定的CBZ治疗,GGT升高.
- 12名患者符合标准,并从CBZ突然切换到LCM.
- 在转换后的一个月内,监测了GGT水平和发病率.
主要成果:
- 从CBZ转换为LCM导致中位数GGT水平显著下降,从141.5 IU/L降至63.5 IU/L (p=0.0005).
- 患有异常GGT水平的患者比例显著下降,从100%降至66.7% (p=0.008).
- 在1个月的随访期间,没有观察到明显的发病率增加.
结论:
- 从卡巴马西平 (CBZ) 突然切换到胺 (LCM) 是一种有效的策略,以减少焦点患者的高GGT水平.
- 这种开关看起来是安全的,耐受性很好,在短期内保持了控制,没有交叉定位.
- 拉科萨米德为患有CBZ诱导的肝酶升高的患者提供了可行的替代方案.
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